Our group has developed a new method for relating the measured extracellular potentials to the current source density (CSD) of a cortical column. This method is called the iCSD method (i for inverse). We have also developed a method for estimating the firing rates and synaptic inputs of cortical populations, based on laminar recordings, called laminar population analysis (LPA). The third project of my PhD relates on the extracellular signature of an action potential to the neurons morphology and passive electrical parameters, while the forth project is testing the experimental procedure: extracellular recording of potential -> frequency-filtering, splitting into MUA and LFP -> computing the CSD and estimating the population firing rate. This procedure is executed in a computer model of a cortical population of L5 pyramidal neurons.
|New method: iCSD||Extracellular spikes||New method: LPA||L5 pyramidal pop.|